The more we learn, the more we discover connections threading through our biochemical world. 10 writing the sixth edition, we have made every effort to preseot these connections in a way that will help first-time students of biochemistry understand the subject and how very relevant it is to their lives.
Biochemistry is returning to its roots to renew the study of its role in physiology, with the tools of molecular biology and the information gained from gene sequencing in hand. In the sixth edition, we emphasize that an understanding of biochemical pathways is the underpinning for an understanding of physiological systems. Biochemical pathways make more sense to students when they understand how these pathways relate to the physiology of familiar activities such as digestion, respiration, and exercise. In this edition, particularly in the chapters on metabolism, we have taken several steps to ensure that students have a view of the bigger picture:
• Discussions of metabolic regulation emphasize the everyday conditions that determine regulation: exercise versus rest; fed versus fasting.
• New pathway-integration figures show how multiple pathways work together under a specific condition, such as during a fast.
• More physiologically relevant examples have been added throughout the book.
This physiological perspective is also evident in the new chapter on drug development. The use of a foreign compound to inhibit a specific enzyme sometimes has surprising physiological consequences that reveal new physiological principles
Evolutionary perspectives greatly enable and enhance the study of biochemistry. As Theodosius Dobzhansky noted, “nothing in biology makes sense except in the light of evolution.” Tn the course of evolution, mutations altered many proteins and biochemical motif.~ so that they perform different functions while maintaining their core biochemical elements . .By examining related proteins, we highlight essential chemical features as well as the specialization necessary for particular functions. The tracks of evolution are clear from the analysis of gene and protein sequences.
Authors: Berg, Jeremy Mark. Biochemistry / Jeremy M. Berg, John L. Tymoczko, Lubert Stryer
Publisher: Example Product Manufacturer (2006)